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Cosmeceuticals represent the fastest-growing sector of the skincare industry, with anti-aging products driving much of this growth. Marketing claims for these products often highlight certain formulation guidelines as key to achieving healthier, more youthful-looking skin. These guidelines typically include the exclusion of potentially problematic ingredients, the inclusion of naturally-derived ingredients, and the presence of clinically proven actives at efficacious levels, often referred to as ‘medical grade. This study aimed to evaluate the effectiveness of a novel 3-step ‘medical grade’ skincare regimen, free from parabens, sulfates, and dyes, which combines high levels of unique actives with botanical and marine extracts. Subjects followed a 3-step regimen and were assessed at baseline and biweekly over a 12-week period using digital photography and clinical evaluation by a board-certified dermatologist. The objective was to determine the impact of this multi-ingredient regimen on four specific skin parameters: the appearance of lines and wrinkles, redness, skin tone evenness, and skin texture. Preliminary results after 4 weeks of twice-daily use showed significant improvement in all four clinical parameters compared to baseline, with further improvements observed at 12 weeks.